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Prashant Bagherwal ¹, Akash P. Dahake ², Chirantan Chakma ³

Affiliations
1 Bhupal Nobel's College of Pharmacy, Udaipur, Rajasthan, IN
2 Dept. Of Pharma, Chemistry B. Pharmacy College, Rampura, Kakanpur Godhara, Gujarat, IN
3 Pharmacy College, Rampura, Godhra, Gujarat, IN

Abstract

Aqueous extract of ischolar_mains of Glycyrrhiza glabra was evaluated for immunomodulatory activity using E. coli induced abdominal sepsis, Carbon clearance test, Haemagglutination antibody titre value and delayed type hypersensitivity at different dose levels i.e. 75, 150 and 300 mg/kg of body weight p.o. The results of the studies were compared with the control group. The extract was found to be effective in reducing mortality in E.coli induced abdominal sepsis. The immunostimulant effect was observed with increased phagocytosis in carbon clearance test. The extract was found to have significant immunostimulant activity in haemaggultination antibody titre value and delayed type hypersensitivity at dose levels of 150 and 300 mg/kg of body weight.

Keywords

Glycyrrhiza glabra, Sepsis, Haemagglutination, Hypersensitivity.

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Akash P. Dahake ¹, Rita C. Chakma ², Chirantan Chakma ², Deshbandhu Joshi ²

Affiliations
1 Dept. of Pharmaceutical Chemistry, Pharmacy College, Rampura, Godhara, Dist: Panchamahal, Gujarat, IN
2 Pharmacy College, Rampura, Kakanpur, Godhara, Dist. Panchmahal, Gujarat, IN

Abstract

The investigation was carried out to study the antibacterial and antiinflammatory of the Roccella belangeriana (Lichens) in carrageenan induced rat paw oedema im albino rats. Antimicrobial activity of the acetone and aqueous extracts of Roccella belangeriana were determined against various pathogenic bacteria. The extracts were tested against various bacteria like Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli by disk diffusion method. Minimum Inhibitory Concentration (MIC) values of both extracts were determined. It is concluded that acetone extract exhibited significant antimicrobial activity. Acetone extarct of Roccella belangeriana was given at a dose of 100, 200 and 300 mg/kg of body weight (p.o) and standard drug, Diclofenac sodium at a dose of 100 mg/kg. The paw oedema volume was determined for 3 hours at every one hour interwal. The extract exhibited dose dependent activity at all three dose levels. This Study lends sceintific support for it's use in folk medicine.

Keywords

Roccella belangeriana, Carrageenan, Antimicrobial, Anti-Inflammatory.

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Akash P. Dahake ¹, Arun B. Joshi ², Krunal M. Patel ³

Affiliations
1 Dept. of Pharma. Chemistry, B. Pharmacy College, Rampura, Kakanpur, Godhara, Gujarat, IN
2 N.G.S.M Institute of Pharm.Sciences, Paneer, Dearalaktte, Mangalore, IN
3 Pharmacy College, Rampura, Kakanpur, Godhara, Panchmahal, Gujarat, IN

Abstract

Increasing prevalence of multidrug resistant strains of microorganisms has initiated the exploration of alternate antimicrobial agent. Taking into account the medicinal importance of Dolichos Lablab (Fabaceae) in this respect, an attempt was made in the current study to investigate the antimicrobial potential of this plant. Antimicrobial activity of the ethanolic, petroleum ether, aqueous, chloroform, ethyl acetate and nhexane extracts of Dolichos Lablab beans were determined against various pathogenic bacteria and fungi. The extracts were tested against various bacteria like Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and fungi like Candida albicans by disk diffusion method. Minimum Inhibitory Concentration (MIC) values of each active extract were determined. It is concluded that n-Hexane and chloroform extract exhibited significant antimicrobial and antifungal activity.

Keywords

Dolichos Lablab, Antibacterial, Antifungal, Disk Diffusion Method.

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Akash P. Dahake ¹, D. Satyanarayana ¹, Arun B. Joshi ¹, K. S. Chandarshekhar ¹, Himanshu Joshi ¹

Affiliations
1 Dept. of Pharmacognosy, N.G.S.M Institute of Pharmaceutical Sciences, Paneer, Deralakatte, Mangalore-574160, IN

Abstract

The investigation was carried out to study the antihyperglycemic effects of ethanolic extract of Anacardium occidentale leaves in normal, glucose loaded and alloxan induced diabetic rats. The ethanolic extract of A. occidentale at a dose of 100, 200, 400 mg/kg of body weight (p.o) and standard drug glibenclamide 500 μg/kg, in all three animal models. The serum glucose level was determined at 0, 4, 8 and 12 days after treatment. The extract exhibited significant hypoglycemic activity in all three animal models when compared with a standard antidiabetic agent Glibenclamide. The hypoglycemia produced by the extract may be due to increased uptake of glucose at tissue level and or increase in pancreatic β-cell function or due to inhibition of intestinal glucose absorption of glucose. The study indicated that the ethanolic extract of Anacardium occidentale is a potential antidiabetic agent and lends scientific support for it’s use in folk medicine.

Keywords

Anacardium occidentale, Diaebetes, Alloxan.

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